Cheryl Brandenburg, PhD
Postdoc, T32 fellow
Contact: cherylbrandenburg{at}som.umaryland.edu
Lab space: HSF3 room 9130
Cheryl’s publications on Google Scholar
Cheryl’s research goals center around developing support for individuals with autism after having worked as an in-home therapist for children on the spectrum. Her dissertation studies focused on postmortem autism brain tissue and uncovering circuit alterations across individuals. The cerebellum and basal ganglia became her primary regions of interest and, as a postdoc, she is currently working to characterize the impact of autism-associated genes on the development of cerebellar circuitry. To accomplish this, she has optimized techniques for CRISPR genome editing, cerebellar in utero electroporation, clearing and light sheet imaging of rodent brains to quantify Purkinje topography in a 3D space. By understanding circuit and signaling alterations, Cheryl hopes to one day understand the cerebellum’s contribution to challenging sensorimotor behaviors in autism.
Supported by:
Posts featuring Cheryl:
Neuroligin-3 paper gets the cover of Biological Psychiatry!
Congrats to Bek Altas and other lab members, as well as our collaborators at the Max Planck Institute for Multidisciplinary Sciences and the University of Turin. Our paper on the synaptic localization of Neuroligin-3 in the mouse and human brain and the molecular mechanism that regulates it, became the cover article on this month’s issue of Biological Psychiatry! Congrats to Cheryl Brandenburg for the cover art and the epic experiment that inspired it, one of the first ever immunolabelings of excitatory and inhibitory synapses in the human brain!
Cheryl’s light sheet electroporated hippocampus on the cover of JCN!
Our paper with Gene Blatt in Journal of Comparative Neurology on the evolution of neuroanatomical tracing methods came out today with Cheryl’s beautiful electroporated, cleared, and light sheet imaged hippocampus gracing the cover, alongside Dee Pandya’s India Ink traces. Happy New Year everyone!
Neuroligin-3 paper out in Biological Psychiatry!
Just out, our paper on the biology of a synaptic adhesion molecule critically implicated in autism, published in Biological Psychiatry!
This massive paper includes outstanding work from scientists and collaborators at the Max Planck Institute for Multidisciplinary Sciences in Germany, and the University of Turin in Italy. It includes some of the first ever imaging of human synapses (spot the cool cup-shaped presynaptic terminals nestled in the human brainstem ????!), and identifies a molecular mechanism that determines the synaptic localization and transmitter-specificity of Neuroligin-3 between excitatory and inhibitory synapses in the brain. Congrats to everyone involved, a great way to end the year!
Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses