Cheryl Brandenburg

Cheryl Brandenburg, PhD

Postdoc, T32 fellow

Contact: cherylbrandenburg{at}

Lab space: HSF3 room 9130

Cheryl’s publications on Google Scholar

Cheryl’s research goals center around developing support for individuals with autism after having worked as an in-home therapist for children on the spectrum.  Her dissertation studies focused on postmortem autism brain tissue and uncovering circuit alterations across individuals.  The cerebellum and basal ganglia became her primary regions of interest and, as a postdoc, she is currently working to characterize the impact of autism-associated genes on the development of cerebellar circuitry.  To accomplish this, she has optimized techniques for CRISPR genome editing, cerebellar in utero electroporation, clearing and light sheet imaging of rodent brains to quantify Purkinje topography in a 3D space.  By understanding circuit and signaling alterations, Cheryl hopes to one day understand the cerebellum’s contribution to challenging sensorimotor behaviors in autism.

Supported by:

Posts featuring Cheryl:

Cas9-RC on the cover of The CRISPR Journal!

Ryan Richardson’s paper describing the development of Cas9-RC, a new CRISPR agent with increased performance for knockin, is out in the October 2023 issue of The CRISPR Journal.

Not only that, but the paper got the cover! Kudos to Cheryl Brandenburg for the beautiful image of knockin neurons and astrocytes using Cas9-RC in the developing mouse brain. Congrats to the whole team for concluding this large piece of Synth Bio meets Dev Neurosci!

We would be delighted to have you try out Cas9-RC for your own knockin needs. Plasmids will become available on Addgene within the next few days!

Cas9-RC Knockin on the cover of The CRISPR Journal

PouLab at SfN 2022

Follow our science at the 4 PouLab posters at SfN 2022 in San Diego!

Cheryl Brandenburg on Monday morning (Y5):
Light sheet mapping of parvalbumin subtypes of Purkinje cells using in vivo CRISPR strategies

Colin Robertson on Monday afternoon (YY36):
Neural somatic genome editing in the brain for personalized patient models

Garrett Bunce and Ro Whitten on Wednesday morning (B31):
The novel gene Ganon-1 produces a scaffolding RNA for growth signaling in developing axon projections

Andrea Romanowski on Wednesday morning (C45):
Mosaic Cas9 fusions to investigate cortical wiring by IgLON schizophrenia risk-genes in the rodent brain”

See you all at #SFN2022

Dr. Cheryl Brandenburg receives SfN Trainee Professional Development Award!

See Cheryl’s light sheet-imaged Purkinje Cells in 3D and the rest of the lab’s research at #SfN2022 in San Diego!