Saovleak Khim

Saovleak (Noury) Khim

Postbac, STAR-PREP Scholar

BSc, Cell & Molecular Neuroscience, Temple University

Research is formalized curiosity. It is poking and prying with purpose.”
– Zora Neale Hurston
I am broadly interested in the mechanisms underlying neuropsychiatric disorders in efforts to accelerate novel therapeutics for treatment-resistant patients. My current project involves the development of in vivo genome editing to investigate a family of receptor tyrosine phosphates (PTPRs) that are tightly regulated during brain development and implicated in Schizophrenia and Autism Spectrum Disorders. I am fascinated by how the brain develops and generates the Human Experience. Outside of the lab, you’ll find me playing volleyball, cooking, or experimenting with coffee.
Check out my latest data using the Aeropress: 
Coffee: 30 grams
Granulation: 4/10 (1=very fine, 10=very coarse)
Water: 70 ml at 90.5°C
Brewer: Inverted
Filter: Paper
Total extraction time:  90 sec
 Enjoy! ☕🤓

Contact: skhim{at}som.umaryland.edu

Lab space: Microscopy suite, HSF3 room 9168

Posts with Noury:

Getting creative to keep science strong in the pandemic

Noury Khim, unflinching scientist vs. the pandemic! Taking on the hurdles of social distancing, Noury live streams a procedure from a head mounted phone to train the lab’s incoming graduate students. To research and teach against all odds, you gotta be strong… #ScienceWomanStrong

Congrats to Ryan and co. for “Cas9 fusions for precision in vivo editing” out on the bioRxiv!

The lab’s first pub is a nifty piece of synth bio for genome editing the brain. Richardson et al. describe a platform to test and develop new high-precision genome editing reagents. Some of our new CRISPR fusions, like eRad18-Cas9-CtIP with linear donors, showed up to 45-times higher accuracy at point-mutation editing compared to vanilla CRISPR. Another step toward direct in vivo knockin and in situ gene therapy approaches!

https://www.biorxiv.org/content/10.1101/2020.07.15.199620v1

The Lab goes to Chicago…

(photo by T. Soykan)

The lab has fun recreating Raphael’s “The School of Athens” in Chicago, while presenting at the 2019 meeting of the Society for Neuroscience!

Ryan, Marilyn, and Jeffrey unveiled their new approach to high efficiency in vivo genome engineering with in situ CRISPR:
https://www.abstractsonline.com/pp8/#!/7883/presentation/65807

Bek, Andrea, Noury, and Uriel debuted their findings on how a mutation in a family with intellectual disability affects the dynactin complex and cortical circuit wiring:
https://www.abstractsonline.com/pp8/#!/7883/presentation/66733

Alex presented new findings on how phosphorylation of Neuroligin adhesion molecules determines synapse specificities:
https://www.abstractsonline.com/pp8/#!/7883/presentation/58703

And how reciprocal adhesion gradient matching guides the development of cortical circuitry:
https://www.abstractsonline.com/pp8/#!/7883/presentation/63936

… and Garrett stashed us some sweet top-shelf probes…