Prime editing, developed by the Liu Lab (Anzalone et al. Nature 2019), enables “search-and-replace genome editing” using a Cas9 and Reverse Transcriptase fusion and hybrid pegRNA. The PegAssist web app guides you through pegRNA design for your favorite genome mutation. Help us beta test PegAssist and let us know how to make it better!
Noury Khim, unflinching scientist vs. the pandemic! Taking on the hurdles of social distancing, Noury live streams a procedure from a head mounted phone to train the lab’s incoming graduate students. To research and teach against all odds, you gotta be strong… #ScienceWomanStrong
Colin Robertson comes to us from the Program in Neuroscience, with a particular interest in synapse pruning and circuit maturation. From day one, Colin (on the left) fit right in…! More soon on the exciting new science he’s after!
Cheryl Brandenburg comes to us from the Hussman Institute, and brings with her a PhD in Neuroscience, a knack for cerebellar circuits, and a passion for autism research! We’re excited to see where she takes her science next…!
Congratulations to PIN postdoctoral fellow Dr. Bekir Altas for winning the Postdoctoral Fellow Excellence in Mentorship Award for an outstanding record of supportive mentorship to PIN and GPILS trainees! pic.twitter.com/RJNx37O9lJ
— Univ of Maryland School of Medicine Neuroscience (@UMMedNeuro) October 26, 2020
The lab’s first pub is a nifty piece of synth bio for genome editing the brain. Richardson et al. describe a platform to test and develop new high-precision genome editing reagents. Some of our new CRISPR fusions, like eRad18-Cas9-CtIP with linear donors, showed up to 45-times higher accuracy at point-mutation editing compared to vanilla CRISPR. Another step toward direct in vivo knockin and in situ gene therapy approaches!
And now some good news for a change… BIG CONGRATS to Marilyn Steyert and Uriel Jean-Baptist for cleaning house on their graduate school applications!
Come next semester, Marilyn will be a PhD student in the Biomedical Sciences (BMS) Program at UC San Francisco, and Uriel will be a PhD student in the Biological & Biomedical Sciences Program (BBSP) at UNC Chapel Hill. We will miss you both, and you both will make us proud!