Congrats to Paige, Garrett, and the Mathur Lab team for their J Physiology paper “Cortical control of striatal fast-spiking interneuron synchrony“. Garrett’s first paper, yay!
Garrett models how cortical networks instruct the striatum
PouLab posters get prizes at the 2022 PiN Retreat!
Two-out-of-two for the lab’s posters at this year’s Program in Neuroscience retreat! Colin Robertson got the “Most innovative experimental design” prize for his poster on “In Vivo Prime Editor Introduces Patient Epilepsy Mutation in the Rodent Brain to Recapitulate Seizures” and Andrea Romanowski accepted a crown and scepter for the “Rule a kingdom” prize for her poster on “Multiplexed manipulation of gene dosage of schizophrenia risk genes using Cas9 fusions changes layer position of cortical neurons”. Congrats PouLab grad students!!!
How an mTOR pathway gene causes epilepsy in a pedigree dating from 1727
Congratulations to Philip Iffland and the Peter Crino Lab –with help from PouLab grad student Andrea Romanowski among the collaborator team– for the publication of a massive piece of work just out in Brain, spanning the fields of human genetics, cell biology, genome editing, electrophysiology, and brain development to identify the gene (NPRL3) and mechanisms that cause epilepsy in affected patients.
“NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination, and seizure threshold” Brain, 2022
Growth cone sorting in Nature Protocols
Our protocol on subtype-specific growth cone sorting by Engmann and Hatch et al. is out on Nature Protocols today from Alex’s old team in the Macklis lab@Harvard!
Cheryl Brandenburg receives Autism Research Institute grant!
PouLab postdoc Cheryl Brandenburg was awarded a 2021 Autism Research Institute (ARI) grant for her work on “Cerebellar Circuits in 3D: Screening autism-associated genes in cleared brains with in utero CRISPR genome editing“. Congratulations Cheryl!!! Here is just a snippet of the mind-bending 3D cerebellar circuits from Cheryl’s in vivo edited Purkinje cells…!
Ryan’s article on advancing scientific excellence through inclusivity at the NIH BRAIN Initiative is out in Neuron!
Lab alum, Ryan R. Richardson, now a AAAS STP fellow at the NIH BRAIN Initiative, together with colleagues deputy Director Andrea C. Beckel-Mitchener, Director John Ngai, and program Director Devon C. Crawford, published a paper today in Neuron, outlining how BRAIN’s mission for scientific excellence is empowered by tapping into the full spectrum of diverse talents and perspectives. We’re grateful for your work in advancing opportunities and excelling innovative neuroscience research through inclusion and diversity!
Corinne Martin joins the team as the lab’s first Nathan Schnaper Intern!
Corinne Martin, a rising sophomore majoring in Bioengineering at the University of Maryland, College Park, joined the lab as part of the Nathan Schnaper Intern Program in Translational Cancer Research (NSIP).
Corinne is working on the genetic intersections between neoplasia and brain development, mining patient genome databases and using in vivo genome editing to probe effects on brain circuit development.
Getting creative to keep science strong in the pandemic
Noury Khim, unflinching scientist vs. the pandemic! Taking on the hurdles of social distancing, Noury live streams a procedure from a head mounted phone to train the lab’s incoming graduate students. To research and teach against all odds, you gotta be strong… #ScienceWomanStrong
Lab Welcomes Newest PhD Student, Colin Robertson!
Colin Robertson comes to us from the Program in Neuroscience, with a particular interest in synapse pruning and circuit maturation. From day one, Colin (on the left) fit right in…! More soon on the exciting new science he’s after!
Lab gets a new postdoc, welcome Dr. Cheryl Brandenburg!
Cheryl Brandenburg comes to us from the Hussman Institute, and brings with her a PhD in Neuroscience, a knack for cerebellar circuits, and a passion for autism research! We’re excited to see where she takes her science next…!
