Congrats to Bek and Alex for Postdoctoral Fellow Excellence in Mentorship and Teacher of the Year Awards!

Bek Altas and Alex Poulopoulos were Awarded by the Graduate School of Life Sciences with the 2020 Postdoctoral Fellow Excellence in Mentorship Award and Teacher of the Year Award, a lab dynamic duo in mentorship!!!

Congrats to Ryan and co. for “Cas9 fusions for precision in vivo editing” out on the bioRxiv!

The lab’s first pub is a nifty piece of synth bio for genome editing the brain. Richardson et al. describe a platform to test and develop new high-precision genome editing reagents. Some of our new CRISPR fusions, like eRad18-Cas9-CtIP with linear donors, showed up to 45-times higher accuracy at point-mutation editing compared to vanilla CRISPR. Another step toward direct in vivo knockin and in situ gene therapy approaches!

Look out for these PouLab super stars at UNC and UCSF !

And now some good news for a change… BIG CONGRATS to Marilyn Steyert and Uriel Jean-Baptist for cleaning house on their graduate school applications!

Come next semester, Marilyn will be a PhD student in the Biomedical Sciences (BMS) Program at UC San Francisco, and Uriel will be a PhD student in the Biological & Biomedical Sciences Program (BBSP) at UNC Chapel Hill. We will miss you both, and you both will make us proud!


The Lab goes to Chicago…

(photo by T. Soykan)

The lab has fun recreating Raphael’s “The School of Athens” in Chicago, while presenting at the 2019 meeting of the Society for Neuroscience!

Ryan, Marilyn, and Jeffrey unveiled their new approach to high efficiency in vivo genome engineering with in situ CRISPR:!/7883/presentation/65807

Bek, Andrea, Noury, and Uriel debuted their findings on how a mutation in a family with intellectual disability affects the dynactin complex and cortical circuit wiring:!/7883/presentation/66733

Alex presented new findings on how phosphorylation of Neuroligin adhesion molecules determines synapse specificities:!/7883/presentation/58703

And how reciprocal adhesion gradient matching guides the development of cortical circuitry:!/7883/presentation/63936

… and Garrett stashed us some sweet top-shelf probes…