Ro Archives - Poulopoulos Lab

October 15, 2024November 21, 2024

Neuroligin-3 paper gets the cover of Biological Psychiatry!

Congrats to Bek Altas and other lab members, as well as our collaborators at the Max Planck Institute for Multidisciplinary Sciences and the University of Turin. Our paper on the synaptic localization of Neuroligin-3 in the mouse and human brain and the molecular mechanism that regulates it, became the cover article on this month’s issue of Biological Psychiatry! Congrats to Cheryl Brandenburg for the cover art and the epic experiment that inspired it, one of the first ever immunolabelings of excitatory and inhibitory synapses in the human brain!

December 28, 2023December 28, 2023

Neuroligin-3 paper out in Biological Psychiatry!

Just out, our paper on the biology of a synaptic adhesion molecule critically implicated in autism, published in Biological Psychiatry!

This massive paper includes outstanding work from scientists and collaborators at the Max Planck Institute for Multidisciplinary Sciences in Germany, and the University of Turin in Italy. It includes some of the first ever imaging of human synapses (spot the cool cup-shaped presynaptic terminals nestled in the human brainstem ????!), and identifies a molecular mechanism that determines the synaptic localization and transmitter-specificity of Neuroligin-3 between excitatory and inhibitory synapses in the brain. Congrats to everyone involved, a great way to end the year!

November 11, 2023November 11, 2023

PouLab posters at SfN 2023

Calling all Neuroscientists!!!

Come check out all the PouLab posters at SfN 2023

Sunday pm session: “Genetic Techniques to Target and/or Manipulate Cells”, three back-to-back posters :

VV22: Find out what the best tag is for labeling your protein by Knockin at Andrea Romanowski‘s poster
https://www.abstractsonline.com/pp8/#!/10892/presentation/39783
VV23: Learn about how some genes are resistant to CRISPR-activation at Ashley Marquardt‘s poster
https://www.abstractsonline.com/pp8/#!/10892/presentation/39785
VV24: Get to see Neuroligin 3 for the first time in the human brain and how it might be used against brain cancer at Ro Whitten‘s poster
https://www.abstractsonline.com/pp8/#!/10892/presentation/39784

Monday am session “Animal Models of Epilepsy: Genetics and Pharmacology”:

C57: Learn about an exciting new way to model individual epilepsy patients in mice using prime editing from Colin Robertson‘s poster
https://www.abstractsonline.com/pp8/#!/10892/presentation/32416

Wednesday pm session “Mechanisms Underlying Axon Growth and Targeting”:

B14: Hear about a strange non-coding RNA that is involved in axon growth and potentially regeneration at Garrett Crutcher‘s poster
https://www.abstractsonline.com/pp8/#!/10892/presentation/33556

Celebrate neuroscience with us!!!

November 13, 2022November 14, 2022

PouLab at SfN 2022

Follow our science at the 4 PouLab posters at SfN 2022 in San Diego!

Cheryl Brandenburg on Monday morning (Y5):
“Light sheet mapping of parvalbumin subtypes of Purkinje cells using in vivo CRISPR strategies“

Colin Robertson on Monday afternoon (YY36):
“Neural somatic genome editing in the brain for personalized patient models“

Garrett Bunce and Ro Whitten on Wednesday morning (B31):
“The novel gene Ganon-1 produces a scaffolding RNA for growth signaling in developing axon projections“

Andrea Romanowski on Wednesday morning (C45):
“Mosaic Cas9 fusions to investigate cortical wiring by IgLON schizophrenia risk-genes in the rodent brain”

See you all at #SFN2022

September 19, 2022November 10, 2022

New PhD student Ro Whitten joins the lab!

Ro Whitten, a developmental neuroscientists by training from U of Rochester and postbac at the NIH, joins the lab in style! Welcome Ro!

Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses