The lab’s first pub is a nifty piece of synth bio for genome editing the brain. Richardson et al. describe a platform to test and develop new high-precision genome editing reagents. Some of our new CRISPR fusions, like eRad18-Cas9-CtIP with linear donors, showed up to 45-times higher accuracy at point-mutation editing compared to vanilla CRISPR. Another step toward direct in vivo knockin and in situ gene therapy approaches!
(photo by T. Soykan)
The lab has fun recreating Raphael’s “The School of Athens” in Chicago, while presenting at the 2019 meeting of the Society for Neuroscience!
Ryan, Marilyn, and Jeffrey unveiled their new approach to high efficiency in vivo genome engineering with in situ CRISPR:
Bek, Andrea, Noury, and Uriel debuted their findings on how a mutation in a family with intellectual disability affects the dynactin complex and cortical circuit wiring:
Alex presented new findings on how phosphorylation of Neuroligin adhesion molecules determines synapse specificities:
And how reciprocal adhesion gradient matching guides the development of cortical circuitry:
… and Garrett stashed us some sweet top-shelf probes…
Congratulations to Andrea Romanowski for passing her qualifying exam and advancing to PhD candidacy with flying colors!
Andrea and Garrett spreading the love for neuroscience at Windsor Hills Elementary and Middle School!
Learn more at UMB NOVA (Neuroscience Outreach and Volunteer Association)
Do we use the windows as white boards? We sure do.
Today is the first day for Ben Grosso (Program in Biochemistry & Molecular Biology) and Garrett Bunce (Program in Neuroscience) in the lab, kicking off the first round of 2019 lab rotations for GPILS students. Andrea and Marilyn introduce the new lab members to the lab’s science…
Andrea Romanowski, from the Program in Molecular Medicine, becomes the lab’s 1st PhD student! Andrea’s first official day of PhD work, July 26, is also the day that, exactly 100 years ago, Emmy Noether published a paper outlining her eponymous theorem. Auspicious beginnings for the future Dr. Romanowski!
Moving day is here! Time for the Poulopoulos Lab to get a new home across the street in Health Sciences Facility III.
Equipment needs bubble wrap, heavy things need lifting, scopes come apart and back together again. And in the midst of this madness, our science doesn’t miss a beat! The heroic investigators of the lab continued cloning and perfusing in between filling crates and hauling off incubators. Everyone working hard… except the guy behind the camera, that is.
Goodbye old lab… hello vista from the 9th floor of the new and improved PouLab!!!