Our work on how the synaptic adhesion molecule Neuroligin-3 is targeted to either excitatory or inhibitory synapses based on phosphorylation is now available on the
bioRxiv! Congrats to Bekir Altas, Liam Tuffy, Annarita Patrizi and the rest of the team in this international collaboration between the University of Maryland School of Medicine, the Max Planck Institute for Multidisciplinary Sciences, and the University of Turin.
Phosphorylation Determines Whether Neuroligin-3 is at Excitatory or Inhibitory Synapses in Different Regions of the Brain
Garrett hosts NOVA’s Halal on the Lawn, then gives a talk on the lncRNA he discovered; Andrea does supply runs, then gives a talk on multiplexing schizophrenia risk genes with CRISPR; Elise handles donation logistics, and attends both talks! And at the end of a good day’s work, the lab celebrates Alex’s birthday.
Read all about our postulate of the curious little things called “mTOR outposts” in this Hypothesis & Theory paper just out in
Frontiers in Cellular Neuroscience!
Neuronal mTOR Outposts: Implications for Translation, Signaling, and Plasticity
Happy day for
Bek, Andrea, Garrett, and Alex. Appreciations to Helen Bateup and Akira Yoshii for very constructive reviewing; to Gerardo Morfini for editing the Kinase/phosphatase signaling and axonal function in health and disease topic; and to all in the acknowledgements for the fascinating discussions around the concepts in the mTOR outpost model. Be part of those discussions, send us your thoughts!
Congrats to Paige,
Garrett, and the Mathur Lab team for their J Physiology paper “ Cortical control of striatal fast-spiking interneuron synchrony“. Garrett’s first paper, yay!
We’ve all had extra time to think about stuff we might otherwise not. Garrett’s neighborhood seems to be thinking a lot about brains! Now his neighbors get a shot at some answers…!
(photo by T. Soykan)
The lab has fun recreating Raphael’s “
The School of Athens” in Chicago, while presenting at the 2019 meeting of the Society for Neuroscience!
Ryan, Marilyn, and Jeffrey unveiled their new approach to high efficiency
in vivo genome engineering with in situ CRISPR:
Bek, Andrea, Noury, and Uriel debuted their findings on how a mutation in a family with intellectual disability affects the dynactin complex and cortical circuit wiring:
Alex presented new findings on how phosphorylation of Neuroligin adhesion molecules determines synapse specificities:
And how reciprocal adhesion gradient matching guides the development of cortical circuitry:
… and Garrett stashed us some sweet top-shelf probes…
Garrett Bunce from the Program in Neuroscience joins the lab. Garrett will apply his training in Systems and Computational Neuroscience to develop recording strategies for listening in on in situ genome engineered rat brains… Welcome Garrett!
Andrea and Garrett spreading the love for neuroscience at Windsor Hills Elementary and Middle School!
Learn more at UMB
NOVA (Neuroscience Outreach and Volunteer Association)
Do we use the windows as white boards? We sure do.
Today is the first day for Ben Grosso (
Program in Biochemistry & Molecular Biology) and Garrett Bunce ( Program in Neuroscience) in the lab, kicking off the first round of 2019 lab rotations for GPILS students. Andrea and Marilyn introduce the new lab members to the lab’s science…